HCID 70358781, compound → HCID 178484878, compound

HRID 622837Notes

Reaction equation

HRID 622837 reaction equation
I.C[O:3][C:4]([C@H:6]1[NH:11][C:10](=O)[N:9]2[CH2:13][N:14](C)[CH:15]=[C:8]2[CH2:7]1)=[O:5]>Cl>[CH3:10][NH:11][C@H:6]([C:4]([OH:5])=[O:3])[CH2:7][C:8]1[N:9]=[CH:13][NH:14][CH:15]=1

Participants

3

Reactant 1

HCID 70358781HCID 70358781, compound

Product 1

HCID 178484878HCID 178484878, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3.37 g (10 mmol) of (+)-(7S)-5,6,7,8-tetra-hydro-7-(methoxycarbonyl)-2-methyl-5-oxoimidazo[1,5-c]pyrimidine hydroiodide is heated under reflux in 40 ml of 6N HCl until no starting compound can be detected any longer by thin-layer chromatography (6-8 hours). Then, the hydrochloric acid is withdrawn under vacuum, the oily residue is taken up in ethanol and crystallized by addition of ether.

Workup

  1. customlonger by thin-layer chromatography (6-8 hours)
  2. customThen, the hydrochloric acid is withdrawn under vacuum
  3. customcrystallized by addition of ether

Sources & evidence

ORD record
ord-d3fd17be6c90442f9eefa50e774d961d
Source dataset
uspto-grants-1988_09
Patent number
US04772721

Reaction notes

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