Triethylamine → HCID 14390490, compound

HRID 622923Notes

Reaction equation

HRID 622923 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.C(N(CC)CC)C.[CH2:18]([O:20][C:21](=[O:31])[CH2:22][NH:23][C:24]1[C:29]([NH2:30])=[CH:28][CH:27]=[CH:26][N:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH2:22][NH:23][C:24]1[C:29]([NH:30][C:8]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=2)=[O:9])=[CH:28][CH:27]=[CH:26][N:25]=1)[CH3:19]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 110951464-chloropyridine-2-carbonyl ChlorideHCID 14390203Ethyl 2-(3-aminopyridin-2-ylamino)acetate

Product 1

HCID 14390490HCID 14390490, compound

Procedure

The crude 4-chloro picolinoyl chloride and triethylamine (5.55 g, 0.055 mole) were added dropwise simulaneously to the above stirred filtrate of N-(3-amino-2-pyridinyl)glycine ethyl ester at room temperature and allowed to stir overnight.

Sources & evidence

ORD record
ord-933ad28f3cb9484c9fa5ce048c49ee70
Source dataset
uspto-grants-1988_09
Patent number
US04772600

Reaction notes

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