Tert-Butylamine → N-tert-butyl-2-amino-3,5-dichlorobenzamide

HRID 623278Notes

Reaction equation

HRID 623278 reaction equation
CO[C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[NH2:12].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>CO>[C:14]([NH:18][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[NH2:12])([CH3:17])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 613050Methyl 2-amino-3,5-dichlorobenzoate

Product 1

HCID 118496623N-tert-butyl-2-amino-3,5-dichlorobenzamideYield 90.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
64 °C

Procedure

To a 100 mL round-bottom flask, 0.1 mol of 2-amino-3,5-dichlorobenzoic acid methyl ester having a structure as shown in VIII-1, 100 mL of methanol, and 0.4 mol of tert-butylamine were added, heated to 64° C. and reacted for 5 hours, after treatment 23.5 grams of N-tert-butyl-2-amino-3,5-dichlorobenzamide having a structural formula of III-1 was obtained, and the yield was 90.4%;

Workup

  1. additionwere added
  2. customreacted for 5 hours

Sources & evidence

ORD record
ord-d84848f7159b4522a4d7d69ea5449e08
Source dataset
uspto-grants-2016_04
Patent number
US09301529B2

Reaction notes

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