1-Methylpiperazine → HCID 87426340, compound

HRID 623484Notes

Reaction equation

HRID 623484 reaction equation
Cl[C:2]1[N:15]=[C:14]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])[CH:13]=[CH:12][C:3]=1[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([C:2]2[N:15]=[C:14]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])[CH:13]=[CH:12][C:3]=2[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 87426801HCID 87426801, compound

Product 1

HCID 87426340HCID 87426340, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (0.71 g, yellow oil) from 2,2,2-trifluoroethyl 2-chloro-6-(2,2,2-trifluoroethoxy)nicotinate (0.75 g, 2.04 mmol, Step-1 of Amine-37) and 1-methylpiperazine instead of morpholine by the similar manner in Step-2 of Amine-37.

Sources & evidence

ORD record
ord-17018e544472435c8a73bbed138b5db3
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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