Isobutyryl chloride → 4-Pyridinecarboxylic acid, 2-[(2-methyl-1-oxopropyl)amino]-, methyl ester

HRID 623553Notes

Reaction equation

Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][N:12]=1)[C:6]([O:8][CH3:9])=[O:7].[C:13](Cl)(=[O:17])[CH:14]([CH3:16])[CH3:15]>>[C:13]([NH:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][N:12]=1)[C:6]([O:8][CH3:9])=[O:7])(=[O:17])[CH:14]([CH3:16])[CH3:15]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 67509862methyl 2-aminoisonicotinate hydrochloride（WS204501）

Product 1

HCID 675091774-Pyridinecarboxylic acid, 2-[(2-methyl-1-oxopropyl)amino]-, methyl esterYield 93%

Procedure

The title compound is prepared in 93% yield (2.20 g, a yellow solid) from methyl 2-aminoisonicotinate hydrochloride (2.00 g, 10.6 mmol) and isobutyryl chloride by the similar manner in Step-1 of Carboxylic acid-1.

Sources & evidence

ORD record: ord-00e82cd9e687489cb5475f1a037c5a2a
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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