反应详情

温度

100 °C

A mixture of 2-acetamido-N-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide (20 mg, 0.05 mmol, Step-1), phenylboronic acid (11 mg, 0.09 mmol), tetrakis(triphenylphosphine)palladium (3 mg, 2.2 microM) in dioxane (2 mL) is added saturated aqueous sodium hydrogencarbonate (0.4 mL). The mixture is heated at 100° C. for 1 hr. After cooled to room temperature, the mixture is extracted with ethyl acetate, dried over sodium sulfate. The organic solvent is removed under reduced pressure. The residue is purified by short column chromatography on amine gel eluting with ethylacetate, and then purified by preparative LC-MS to give 6 mg (30% yield) of the title compound.

1. temperatureAfter cooled to room temperature
2. extractionthe mixture is extracted with ethyl acetate
3. dry with materialdried over sodium sulfate
4. customThe organic solvent is removed under reduced pressure
5. customThe residue is purified by short column chromatography on amine gel
6. washeluting with ethylacetate
7. custompurified by preparative LC-MS