Hydrochloric Acid → HCID 13248576, compound
Reaction equation
C(O[C:6]([N:8](C)[CH2:9][C:10]([CH3:16])([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.Cl.O1CCOCC1>C1COCC1>[CH3:15][C:10]([CH3:16])([CH2:9][NH:8][CH3:6])[C:11]([O:13][CH3:14])=[O:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- -10 °C
Procedure
Under an nitrogen atmosphere, methyl 3-(tert-butoxycarbonyl(methyl)amino)-2,2-dimethylpropanoate (250 mg, 1.019 mmol) was suspended in dry THF (5 mL) and cooled to −10° C. 4.0 M HCl in dioxane (5.10 mL, 20.38 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated under reduced pressure and the residue co-evaporated with DCM (5 mL) to give 185 mg of crude product as a yellow solid.
Workup
- customThe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-bab1531fb975483599616eb770dbb429
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302988B2
Reaction notes
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