反应详情

To a solution of methyl 6-(isoindoline-2-carboxamido)pyridazine-3-carboxylate (3.7 g, 12.4 mmol) in MeOH (40 mL) and THF (40 mL), a solution of LiOH (0.7 g, 29.2 mmol) in water (10 mL) was added at room temperature. The reaction mixture was stirred overnight at room temperature. The reaction mixture was poured into water (100 mL), extracted with EtOAc (2×50 mL) and the aqueous layer was acidified by addition of 2 NHCl to pH 3 to give a precipitate. The precipitate was washed with water and dried in high vacuum to give the title compound.

1. extractionextracted with EtOAc (2×50 mL)
2. additionthe aqueous layer was acidified by addition of 2 NHCl to pH 3
3. customto give a precipitate
4. washThe precipitate was washed with water
5. customdried in high vacuum