反应详情

温度

50 °C

A solution of 3-(benzyloxy)phenol (2.002 g), 2-chloro-N,N-dimethylethanamine (1.459 g) in N,N-dimethylformamide (50 mL) was treated with cesium carbonate (3.91 g) and stirred at 50° C. overnight. The mixture was diluted with ethyl acetate and 1N aqueous NaOH and the layers were separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers were dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography (5% 7N NH; in methanol-dichloromethane) to give the desired product.

1. customthe layers were separated
2. extractionThe aqueous layer was extracted with ethyl acetate
3. dry with materialthe combined organic layers were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by flash chromatography (5% 7N NH; in methanol-dichloromethane)