Ethanol → HCID 71223230, compound

HRID 62451Notes

Reaction equation

HRID 62451 reaction equation
[CH:1]1([C:4]([CH:6]2[C:11](=O)[CH2:10][CH2:9][CH:8]([C:13]([OH:15])=O)[CH2:7]2)=O)[CH2:3][CH2:2]1.[OH2:16].[NH2:17][NH2:18].[CH3:19]CO>>[CH:1]1([C:4]2[C:6]3[CH2:7][CH:8]([C:13]([O:15][CH3:19])=[O:16])[CH2:9][CH2:10][C:11]=3[NH:18][N:17]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 712237193-(Cyclopropanecarbonyl)-4-oxocyclohexanecarboxylic acid

Product 1

HCID 71223230HCID 71223230, compound

Procedure

To a solution of compound 3-(cyclopropanecarbonyl)-4-oxocyclohexanecarboxylic acid (36.0 g, 0.15 mol) in EtOH (95%, 300 mL) was added hydrazine hydrate (23.0 g, 0.39 mol) at 0° C. The reaction mixture was stirred 18 h at rt. The solvent was concentrated in vacuum to give methyl 3-cyclopropyl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylate (35.0 g). The compound was used in the next reaction without further purification.

Workup

  1. concentrationThe solvent was concentrated in vacuum

Sources & evidence

ORD record
ord-1ca078f319f5472092e5afc71d90845d
Source dataset
uspto-grants-2016_09
Patent number
US09446130B2

Reaction notes

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