Water → HCID 90031458, compound

HRID 624660Notes

Reaction equation

HRID 624660 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=[O:16])=[N:7]1.C(N(CC)CC)C.O>C1COCC1>[CH3:1][S:2]([N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=[O:16])=[N:7]1)(=[O:4])=[O:3]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 78250Indazole-3-carboxylic acid

Product 1

HCID 90031458HCID 90031458, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methanesulfonyl chloride (48.1 μl, 0.617 mmol) was added to a solution of 1H-indazole-3-carboxylic acid (100 mg, 0.617 mmol) and triethylamine (86 μl, 0.617 mmol) in THF (1542 μl) and the mixture was stirred for 1 h. The reaction was then poured into water and extracted twice with EtOAc. The combined organic layers were filtered through MgSO4 and concentrated to give the title compound as a white solid, which was used without further purification.

Workup

  1. extractionextracted twice with EtOAc
  2. filtrationThe combined organic layers were filtered through MgSO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-30f09f79c3e34e5f8e4dc4bca4bae08d
Source dataset
uspto-grants-2016_04
Patent number
US09303045B2

Reaction notes

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