Hydrochloric Acid → HCID 90203546, compound

HRID 624956Notes

Reaction equation

HRID 624956 reaction equation
C(OC([N:8]1[CH2:12][C:11]([CH3:14])([CH3:13])[CH2:10][CH:9]1[C:15](=[O:17])[NH2:16])=O)(C)(C)C.[ClH:18].C(OCC)C>O1CCOCC1>[ClH:18].[CH3:13][C:11]1([CH3:14])[CH2:12][NH:8][CH:9]([C:15]([NH2:16])=[O:17])[CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 90203249HCID 90203249, compound

Product 1

HCID 90203546HCID 90203546, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 2-carbamoyl-4,4-dimethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1.2 g, 4.95 mmol) in dioxane (5 mL) was cooled to 10° C. Hydrogen chloride dissolved in dioxane (10 mL, 6.4 N) was added and the mixture was stirred for 1.5 hours. Diethylether (50 mL) was added to completely precipitate the product, which was filtered and dried to give the title compound (0.84 g, 95%) as colorless solid; MS (ESI) 143.0 [MH+].

Workup

  1. additionwas added
  2. customto completely precipitate the product, which
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-61a01339f9994437a27bdf85444d7f59
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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