Hydrochloric Acid → HCID 90203590, compound

HRID 624979Notes

Reaction equation

HRID 624979 reaction equation
[C:1]([C@H:4]1[N:8](C(OC(C)(C)C)=O)[C:7]([CH3:17])([CH3:16])[CH2:6][CH2:5]1)(=[O:3])[NH2:2].[ClH:18]>O1CCOCC1>[ClH:18].[CH3:16][C:7]1([CH3:17])[NH:8][C@H:4]([C:1]([NH2:2])=[O:3])[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66630658HCID 66630658, compound

Product 1

HCID 90203590HCID 90203590, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in Example 82 a), (S)-tert-butyl 5-carbamoyl-2,2-dimethylpyrrolidine-1-carboxylate (CAN 1292838-05-1) was treated with a 4 M solution of HCl in dioxane to give the title compound as colorless solid which was sufficiently pure to be used in the next step; MS (EI): m/e=143.2 [(M-Cl)H+].

Sources & evidence

ORD record
ord-3dbf7fd3a93e471292f22a33c97388dc
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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