Hydrochloric Acid → HCID 90203343, compound

HRID 624999Notes

Reaction equation

HRID 624999 reaction equation
[C:1]([C@@H:4]1[CH2:8][C:7]([OH:10])([CH3:9])[CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].[ClH:18].O1CCOCC1>>[ClH:18].[OH:10][C:7]1([CH3:9])[CH2:6][NH:5][C@H:4]([C:1]([NH2:2])=[O:3])[CH2:8]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 90204105HCID 90204105, compound

Product 1

HCID 90203343HCID 90203343, compound

Procedure

A solution of (2S)-tert-butyl 2-carbamoyl-4-hydroxy-4-methylpyrrolidine-1-carboxylate (Example 132 a, 46 mg, 188 μmol) in a solution of 4 M HCl in dioxane (942 μL, 3.8 mmol) was stirred at ambient temperature for 5 h. The solvent was removed in vacuo to give the title compound (36 mg, quant.) as light brown solid, MS (ESI) m/e=145.2 [MH+].

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-46e26db8b6aa40b596cd5e6a8bd69ab8
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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