反应详情

A mixture of 1.7 grams (5 mmol) of penta-n-butylguanidine (made as described earlier), 0.686 grams (5 mmol) of 1-bromobutane and 10 ml of isobutyronitrile was heated under reflux for 20 hours. Upon vacuum stripping, a pale yellow oil was obtained which crystallized to a pale brown solid upon standing. Upon recrystallization from a mixture of hexane and ethyl acetate, the desired N,N,N′,N′,N″,N″-hexa-n-butylguanidinium bromide was obtained as a white solid.

1. temperaturewas heated
2. temperatureunder reflux for 20 hours
3. customUpon vacuum stripping, a pale yellow oil was obtained which
4. customcrystallized to a pale brown solid
5. customUpon recrystallization
6. additionfrom a mixture of hexane and ethyl acetate