反应详情

温度

50 °C

Into a 50-mL round-bottom flask, was placed a solution of 4-chloro-6-(2-nitro-5-(piperidin-1-yl)phenyl)pyrimidine (191 mg) in N,N-dimethylformamide (10 mL), and 3-(trifluoromethyl)benzylamine (210 mg). The resulting solution was stirred overnight at 50° C. The resulting mixture was dissolved in 50 mL of ethyl acetate and washed with 2×50 mL of water. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel chromatograpy to give 186 mg of product as yellow oil.

1. customInto a 50-mL round-bottom flask, was placed
2. washwashed with 2×50 mL of water
3. dry with materialThe mixture was dried over anhydrous sodium sulfate
4. concentrationconcentrated under vacuum
5. customThe residue was purified by silica gel chromatograpy