反应详情

温度

120 °C

To a suspension of NaH (1.2 mmol; 50 mg) in anhydrous DMSO (1 mL) under argon, was added 4-ethyl-2-methoxyphenol (1 mmol; 152.2 mg) followed by 2,6-difluoropyridine (1 mmol; 0.1 ml). The reaction mixture was stirred at 120° C. overnight. After quenching with NaOH (0.1N; 3 mL), the mixture was extracted with dichloromethane (3*5 mL). Combined organic phases were dried over Na2SO4, concentrated in vacuo, to give the title compound as a light yellow oil (250 mg; 1 mmol; 100%), used without further purification.

1. customAfter quenching with NaOH (0.1N; 3 mL)
2. extractionthe mixture was extracted with dichloromethane (3*5 mL)
3. dry with materialCombined organic phases were dried over Na2SO4
4. concentrationconcentrated in vacuo