Tetrahydrofuran → HCID 59191347, compound

HRID 626065Notes

Reaction equation

HRID 626065 reaction equation
C([O:8][C:9]1[CH:34]=[C:33]([CH2:35][CH3:36])[CH:32]=[CH:31][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)(=[O:20])=[O:19])=[CH:14][C:13]=1[F:30])C1C=CC=CC=1.O1CCCC1>C(O)C>[CH2:35]([C:33]1[CH:32]=[CH:31][C:10]([O:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][CH2:24][N:25]3[CH:29]=[CH:28][N:27]=[CH:26]3)(=[O:20])=[O:19])=[CH:14][C:13]=2[F:30])=[C:9]([OH:8])[CH:34]=1)[CH3:36]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 59191402HCID 59191402, compound

Product 1

HCID 59191347HCID 59191347, compoundYield 42.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure of example 20 (b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl) phenoxy]benzene for 4-(2-Benzyloxy-4-ethyl-phenoxy)-3-fluoro-N-(3-imidazol-1-yl-propyl)-benzenesulfonamide (160 mg; 0.31 mmol) and tetrahydrofurane for ethanol (3 mL), the title compound (55 mg; 42%) was obtained as a clear oil, after purification via preparative TLC (dichloromethane/methanol/triethylamine)

Sources & evidence

ORD record
ord-e7f1376a3d7441f78eee46697f7393a1
Source dataset
uspto-grants-2016_04
Patent number
US09309179B2

Reaction notes

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