Hydrogen Bromide → HCID 89656205, compound

HRID 626157Notes

Reaction equation

HRID 626157 reaction equation
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][CH2:5][C:6]1[N:11]=[CH:10][C:9]([C:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=2)=[O:13])=[CH:8][CH:7]=1.Br>CO>[CH3:22][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[N:11]=[CH:10][C:9]([C:12]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)=[O:13])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 89655848HCID 89655848, compound

Product 1

HCID 89656205HCID 89656205, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (6-(3-(dimethylamino)propyl)pyridin-3-yl)(4-methoxy-phenyl)methanone (298 mg, 1 mmol) in 10 mL of methanol was added 10 mL of 48% HBr at rt and the mixture was heated to reflux for 3 h and cooled. The solvent was evaporated to give the crude product, which was used without further purification (284 mg, 100% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 h
  3. temperaturecooled
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-3ebe6948413a4c6b90bc0f6bf4fe1df8
Source dataset
uspto-grants-2016_04
Patent number
US09309211B2

Reaction notes

Loading…