Hydrochloric Acid → HCID 131737198, compound

HRID 62623Notes

Reaction equation

HRID 62623 reaction equation
C(OC(=O)[NH:7][C:8]12[CH2:12][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])([CH2:11]1)[CH2:9]2)(C)(C)C.[ClH:18]>CCOC(C)=O>[Cl-:18].[C:13]([C:10]12[CH2:12][C:8]([NH2:7])([CH2:11]1)[CH2:9]2)([CH3:16])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117607715HCID 117607715, compound

Product 1

HCID 131737198HCID 131737198, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl(3-(tert-butyl)bicyclo[1.1.1]pentan-1-yl)carbamate (0.983 g, 4.11 mmol) in EtOAc (10.3 mL) was treated with HCl (4.0M in dioxane, 41.1 mmol, 10.3 mL) and allowed to stir at r.t. overnight. The solution was concentrated under reduced pressure to afford the crude product as an off-white solid. The solid was triturated with Et2O (3×10 mL) to afford compound 15 as a white solid (0.6911 g). MS: m/z 140.2 [M+H]+.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. customto afford the crude product as an off-white solid
  3. customThe solid was triturated with Et2O (3×10 mL)

Sources & evidence

ORD record
ord-9492c261598242c9bb0dd7ecd54154e7
Source dataset
uspto-grants-2016_09
Patent number
US09447026B2

Reaction notes

Loading…