Hydrochloric Acid → 1-(4-Bromophenyl)ethylamine hydrochloride

HRID 626400Notes

Reaction equation

HRID 626400 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][S@](C(C)(C)C)=O)[CH3:9])=[CH:4][CH:3]=1.[ClH:17]>CO>[ClH:17].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86732639HCID 86732639, compound

Product 1

HCID 534848701-(4-Bromophenyl)ethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)—N—((S)-1-(4-bromophenyl)ethyl)-2-methylpropane-2-sulfinamide (170 mg, 0.56 mmol) was dissolved in methanol (2 mL) followed by addition of con.HCl (1 mL). The mixture was stirred at RT for 4 h and then was concentrated and evaporated with toluene twice to afford the titled compound.

Workup

  1. additionfollowed by addition of con
  2. concentrationwas concentrated
  3. customevaporated with toluene twice

Sources & evidence

ORD record
ord-2c4a12918ec54afba31feacce594bbd3
Source dataset
uspto-grants-2016_04
Patent number
US09309227B2

Reaction notes

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