反应详情

The mixture of methyl 1-(4-bromobenzyl)-1H-benzo[d]imidazole-5-carboxylate (650 mg, 1.88 mmol) and LiOH (150 mg, 3.76 mmol) in Methanol (10 mL) and 1120 (5 mL) was stirred at RT overnight. Then the methanol was removed under the reduced pressure to get a residue, pH was adjusted to 7 with 3N HCl to give a large number of precipitation, then filtered and the filter cake was washed by water (5 mL×2), dried under vacuum to give the titled compound.

1. customThen the methanol was removed under the reduced pressure
2. customto get a residue, pH
3. customto give
4. customa large number of precipitation
5. filtrationfiltered
6. washthe filter cake was washed by water (5 mL×2)
7. customdried under vacuum