反应详情

The mixture of 1-(4-bromobenzyl)-1H-benzo[d]imidazole-5-carboxylic acid (521 mg, 1.57 mmol), (S)-1-(3-isopropylphenyl)ethanamine (314 mg, 1.88 mmol), HATU (1.19 g, 1.88 mmol) and DIPEA (607 mg, 4.71 mmol) in DMF (15 mL) was stirred at RT overnight. Then the mixture was poured into 20 mL of water, then extracted with EtOAc (10 mL×3). The combined organic layers was washed with water (10 mL) and brine (10 mL) and dried with Na2SO4. After filtration, the filtrate was concentrated under the reduced pressure. The residue was purified with Combiflash (DCM/EtOAc=4/1, silica gel) to give the title compound.

1. extractionextracted with EtOAc (10 mL×3)
2. washThe combined organic layers was washed with water (10 mL) and brine (10 mL)
3. dry with materialdried with Na2SO4
4. filtrationAfter filtration
5. concentrationthe filtrate was concentrated under the reduced pressure
6. customThe residue was purified with Combiflash (DCM/EtOAc=4/1, silica gel)