反应详情

In one aspect, substrates A and B were prepared as follows. To a solution of (S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanoic acid (1w) in THF was added methyl 2-aminoacetate hydrochloride (2w), Et3N and HATU. The mixture was stirred at room temperature for 16 h. The reaction was filtered through Celite. The reaction filtrate was diluted with 100 mL of water and stirred for 15 min. The suspension was filtered off, rinsed with water and dried to afford (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)acetate (3w).

1. customIn one aspect, substrates A and B were prepared
2. filtrationThe reaction was filtered through Celite
3. additionThe reaction filtrate was diluted with 100 mL of water
4. stirringstirred for 15 min
5. filtrationThe suspension was filtered off
6. washrinsed with water
7. customdried