Cyclopropyl methyl ketone → N-[(E)-1-cyclopropylethylideneamino]-2,4,6-tri(propan-2-yl)benzenesulfonamide

HRID 627268Notes

Reaction equation

HRID 627268 reaction equation
C1(C(=O)C)CC1.[CH:7]([C:10]1[CH:15]=[C:14]([CH:16]([CH3:18])[CH3:17])[CH:13]=[C:12]([CH:19]([CH3:21])[CH3:20])[C:11]=1[S:22]([NH:25]/[N:26]=[C:27](/[CH:29]([CH3:31])[CH3:30])\[CH3:28])(=[O:24])=[O:23])([CH3:9])[CH3:8]>>[CH:29]1(/[C:27](=[N:26]/[NH:25][S:22]([C:11]2[C:12]([CH:19]([CH3:20])[CH3:21])=[CH:13][C:14]([CH:16]([CH3:18])[CH3:17])=[CH:15][C:10]=2[CH:7]([CH3:8])[CH3:9])(=[O:24])=[O:23])/[CH3:28])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 13004Cyclopropyl methyl ketoneHCID 12563993N-[(E)-3-methylbutan-2-ylideneamino]-2,4,6-tri(propan-2-yl)benzenesulfonamide

Product 1

HCID 12735383N-[(E)-1-cyclopropylethylideneamino]-2,4,6-tri(propan-2-yl)benzenesulfonamide

Procedure

The title compound was prepared from 2,4,6-triisopropylbenzenesulfonyl hydrazide (Aldrich, 20 g, 67.01 mmol) and 1-cyclopropylethanone (Aldrich, 6.28 mL, 67.01 mmol) following the procedure described for Intermediate 33. The desired product was obtained as a white solid (15 g, 61%).

Sources & evidence

ORD record
ord-8a4383744e7747509882559eaa8dabe1
Source dataset
uspto-grants-2016_04
Patent number
US09309245B2

Reaction notes

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