反应详情

To a stirred solution of benzofuran-5-ol (2) (257 mg, 1.92 mmol) in DMF (3 mL), NaH (81 mg, 1.92 mmol, 57% dispersion in oil) was added at 0° C. The reaction mixture was warmed to room temperature and stirred 1 hour. Chloromethyl ethyl ether (214 μL, 2.30 mmol) was then added drop wise to 0° C. and the mixture was stirred at room temperature for additional 1 hour. Water (10 mL) was added and the reaction mixture was extracted with ethyl acetate (2×50 mL). The organic extracts were washed with water, brine, dried over Na2SO4, and concentrated in vacuo. Purification of the crude product by flash column chromatography using 10% ethyl acetate in hexane afforded compound (3) (273 mg) as a colourless oil.

1. stirringthe mixture was stirred at room temperature for additional 1 hour
2. extractionthe reaction mixture was extracted with ethyl acetate (2×50 mL)
3. washThe organic extracts were washed with water, brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. customPurification of the crude product by flash column chromatography