反应详情

温度

75 °C

In a 50-mL round-bottom flask was placed a solution of 2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine (250 mg, 1.13 mmol, Intermediate 22, step c), dimethylamine hydrochloride (96 mg, 1.2 mmol), and Et3N (342 mg, 3.39 mmol) in methanol (15 mL). The resulting mixture was heated at 75° C. overnight and concentrated under vacuum. The residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH) to give the title compound as a light yellow solid.

1. customIn a 50-mL round-bottom flask was placed
2. concentrationconcentrated under vacuum
3. customThe residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH)