反应详情

温度

85 °C

To a reaction mixture of tert-butyl ((4aR,11bR)-10-(5-(cyclopropylmethoxy)-3-methylpyrazine-2-carboxamido)-3,3,11b-trimethyl-4,4-dioxido-4a,5,6,11b-tetrahydro-3H-benzo[6,7]oxepino[4,5-b][1,4]thiazin-2-yl)carbamate (40 mg, 0.065 mmol) in DMF 1 ml was added K2CO3 (40 mg, 0.29 mmol). It was heated to 85° C. for 3 h. It was cooled to RT, diluted with water, and extracted with EtOAc. The organic phase obtained was concentrated under reduced pressure and the residue was purified by silica gel chromatography eluting with 15% to 25% to 40% EtOAc/MeOH/Et3N in (40% EtOAc in Heptane) to yield 23 mg of desired product. MS m/z: 514.2 [M+H].

1. temperatureIt was cooled to RT
2. extractionextracted with EtOAc
3. customThe organic phase obtained
4. concentrationwas concentrated under reduced pressure
5. customthe residue was purified by silica gel chromatography
6. washeluting with 15% to 25% to 40% EtOAc/MeOH/Et3N in (40% EtOAc in Heptane)