Ammonium Chloride → HCID 57900489, compound

HRID 627976Notes

Reaction equation

HRID 627976 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])=[C:5]([C:7]2[S:23][C:10]3[C:11]4[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][C:12]=4[O:13][CH2:14][CH2:15][C:9]=3[CH:8]=2)[N:6]=1.[Cl-].[NH4+].C[N:34](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[NH2:1][C:2]1[S:3][C:4]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])=[C:5]([C:7]2[S:23][C:10]3[C:11]4[CH:19]=[CH:18][C:17]([C:20]([NH2:34])=[O:21])=[CH:16][C:12]=4[O:13][CH2:14][CH2:15][C:9]=3[CH:8]=2)[N:6]=1

Participants

6

Reactant 4

HCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 57900345HCID 57900345, compound

Product 1

HCID 57900489HCID 57900489, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following Example 47, 2-(2-amino-5-(2-chlorophenyl)thiazol-4-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylic acid and ammonium chloride were coupled with HATU and DIPEA in DMF to give 268.

Sources & evidence

ORD record
ord-cb3d404bcbd04b888301c06ea404f315
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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