反应详情

Sodium hydride (0.011 g, 0.27 mmol, 60% in mineral oil) was added to a solution of 1,7-dimethyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridine (50.0 mg, 0.268 mmol, from Example 2, Step 5) in DMF (6 mL). After stirring for 10 minutes, (1-bromopentyl)benzene (0.061 g, 0.27 mmol, from Step 1) was added. After stirring for 45 minutes, the reaction was quenched by the addition of water and the mixture was diluted with MeCN, filtered and purified via preparative HPLC-MS (Waters XBridge C18, eluting with a gradient of MeCN/H2O containing 0.15% NH4OH) (0.01 g, 10%).

1. stirringAfter stirring for 45 minutes
2. customthe reaction was quenched by the addition of water
3. additionthe mixture was diluted with MeCN
4. filtrationfiltered
5. custompurified via preparative HPLC-MS (Waters XBridge C18
6. washeluting with a gradient of MeCN/H2O containing 0.15% NH4OH) (0.01 g, 10%)