Water → HCID 136963114, compound

HRID 628403Notes

Reaction equation

HRID 628403 reaction equation
[OH-].[Na+].O.[Br:4][C:5]1[C:6]2[N:7]([C:24]([CH3:27])=[N:25][N:26]=2)[C:8]2[CH:13]=[C:12]([CH3:14])[N:11](S(C3C=CC=CC=3)(=O)=O)[C:9]=2[CH:10]=1>C1COCC1.CCO.CCOCC>[Br:4][C:5]1[C:6]2[N:7]([C:24]([CH3:27])=[N:25][N:26]=2)[C:8]2[CH:13]=[C:12]([CH3:14])[NH:11][C:9]=2[CH:10]=1

Participants

7

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 118159642HCID 118159642, compound

Product 1

HCID 136963114HCID 136963114, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

1.0 M NaOH in water (15 mL, 15 mmol) was added to 4-bromo-1,7-dimethyl-6-(phenylsulfonyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridine (1.57 g, 3.87 mmol, from Step 1) in THF (15 mL) and EtOH (15 mL). The reaction was continued for 1 hour, and a precipitate formed. The solid product was isolated by filtration. The solid was then suspended in Et2O, filtered and air dried. Yield: (0.86 g, 84%).

Workup

  1. customa precipitate formed
  2. customThe solid product was isolated by filtration
  3. filtrationfiltered
  4. customair dried

Sources & evidence

ORD record
ord-39b86aa0a007471eb4ec2514f5a45d23
Source dataset
uspto-grants-2016_04
Patent number
US09309246B2

Reaction notes

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