Bromomethylcyclopropane → 6-Cyclopropylmethylsulfanyl-pyridine-2-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([SH:12])[N:7]=1)=[O:5])[CH3:2].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][CH2:14][CH:15]2[CH2:17][CH2:16]2)[N:7]=1)=[O:5])[CH3:2]Participants
3
Procedure
6-Mercapto-pyridine-2-carboxylic acid ethyl ester (0.54 g, 2.94 mmol) obtained in Step A and bromomethyl cyclopropane were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.568 g, 81%).
Sources & evidence
- ORD record
- ord-de0ae35c9e21402caf8052e30ae81382
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447044B2
Reaction notes
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