反应详情

温度

70 °C

After 6-bromo-pyridine-2-carboxylic acid methyl ester (0.30 g, 1.39 mmol) was dissolved in DMF (4 mL), K2CO3(0.575 g, 4.16 mmol) and cyclohexanethiol (0.25 mL, 2.08 mmol) were added thereto in turn, and the mixture was stirred at 70° C. for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, extracted with EtOAc, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.162 g, 46%).

1. customAfter the termination of the reaction
2. concentrationthe reactant was concentrated under reduced pressure
3. extractionextracted with EtOAc
4. custompurified by column chromatography (eluent, EtOAc/Hex=1/5)