2-Bromopropane → 2-Isopropylsulfanyl-5-methyl-pyridine-3-carbonitrile

HRID 62874Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([C:9]#[N:10])[C:5]([SH:8])=[N:6][CH:7]=1.Br[CH:12]([CH3:14])[CH3:13]>>[CH:12]([S:8][C:5]1[C:4]([C:9]#[N:10])=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=1)([CH3:14])[CH3:13]

Participants

Reactant 2

HCID 63582-Bromopropane

HCID 178430798HCID 178430798, compound

Product 1

HCID 901181222-Isopropylsulfanyl-5-methyl-pyridine-3-carbonitrileYield 70%

Procedure

5-Methyl-2-sulfanyl-pyridine-3-carbonitrile (0.2 g, 1.3 mmol) and 2-bromopropane were reacted in the same manner as in Step A of Preparation Example 5 to obtain the title compound (0.18 g, 70%).

Sources & evidence

ORD record: ord-154b86c51b1e4f9295f017c9fd66c69f
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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