反应详情

A mixture of 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenylamine (915 mg, 2.717 mmol.) in EA (20 ml) and NaHCO3 (20 ml) the reaction was stirred at r.t. then added dropwise to slurry of phenyl chloroformate (851 mg, 0.543 mmol, 2.0 eq) at reaction for 2 hr. The reaction mixture was partitioned between EA/NaHCO3, the organic layer was washed with brine, dried over MgSO4, filtered and evaporated in vacuo. The residue was recrystallized by (Hexane/EtOAc) to give a pale yellow product of 1056 mg (85.1%).

1. additionthen added dropwise
2. customThe reaction mixture was partitioned between EA/NaHCO3
3. washthe organic layer was washed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated in vacuo
7. customThe residue was recrystallized by (Hexane/EtOAc)
8. customto give a pale yellow product of 1056 mg (85.1%)