反应详情

温度

50 °C

A mixture of 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 44.2, 400 mg, 1.011 mmol), ethane-1,2-diol (1 mL, 17.88 mmol), K2CO3 (210 mg, 1.517 mmol) and DMF (2 mL) was stirred at 50° C. overnight. The solvent was evaporated off under reduced pressure and the residue was treated with water and extracted with DCM. The combined extracts were dried over Na2SO4 and the solvent was evaporated off under reduced pressure to afford the title compound which was used directly. UPLC-MS (Condition 2) tR=1.04 min, m/z=421.3/423.3 [M+H]+.

1. customThe solvent was evaporated off under reduced pressure
2. additionthe residue was treated with water
3. extractionextracted with DCM
4. dry with materialThe combined extracts were dried over Na2SO4
5. customthe solvent was evaporated off under reduced pressure