4-Hydroxybenzaldehyde → HCID 57151086, compound

HRID 629135Notes

Reaction equation

HRID 629135 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.I[C:11]1([CH3:17])[CH2:15][CH2:14][CH:13](C)[CH2:12]1.[I-].[Na+]>>[CH:11]1([CH2:17][O:1][C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 1264-HydroxybenzaldehydeHCID 5238Sodium IodideHCID 71040728HCID 71040728, compound

Product 1

HCID 57151086HCID 57151086, compoundYield 51%

Procedure

The compound was synthesized as in Example 24.1, using 4-hydroxybenzaldehyde (200 mg, 1.64 mmol) and 1-iodo-3-methylmethylcyclopentane (344 mg, 0.98 mmol) in place of 1-chloro-3,3-dimethylbutane (no sodium iodide was used) to give 4-(cyclopentylmethoxy)benzaldehyde (102 mg, 50% crude) as a yellow oil that was used without further purification or characterization.

Workup

  1. customThe compound was synthesized as in Example 24.1

Sources & evidence

ORD record
ord-7a3022b3c3d34929ba60ea708c57c95f
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

Loading…