4-Bromobenzaldehyde → 4-Ethylbenzaldehyde

HRID 629145Notes

Reaction equation

HRID 629145 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH2:10](B(O)O)[CH3:11]>>[CH2:10]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[CH3:11]

Participants

3

Reactant 2

HCID 707414-BromobenzaldehydeHCID 521157Ethylboronic acid

Product 1

HCID 208614-EthylbenzaldehydeYield 51.3%

Procedure

The compound was synthesized as in Example 3.1 using 4-bromobenzaldehyde (250 mg, 1.35 mmol) in place of 5-bromo-2-formylfuran and ethylboronic acid (165 mg, 2.23 mmol) in place of hexylboronic acid to give 4-ethylbenzaldehyde (93 mg, 51%). Used without further characterization.

Sources & evidence

ORD record
ord-11db3886e6694943b3515461c16bfdcc
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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