反应详情

(E)-3-(2-Fluoro-4-methoxy-phenyl)-acrylic acid ethyl ester (0.3 g, 1.34 mmol) obtained in Step A was dissolved in THF (10 mL), and diazomethane solution (21.4 mL, 5.36 mmol, 0.25M ether) was added thereto. After the reactant was cooled to 0˜5° C., palladium(II) acetate (45 mg, 0.2 mmol) was added slowly thereto, and the mixture was stirred at room temperature for 5 hours. After the termination of the reaction, the reactant was filtered by using celite, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (0.16 g, 51%).

1. temperatureAfter the reactant was cooled to 0˜5° C.
2. customAfter the termination of the reaction
3. filtrationthe reactant was filtered
4. concentrationconcentrated under reduced pressure
5. custompurified by column chromatography (eluent, EtOAc/Hex=1/10)