反应详情

温度

120 °C

To 7-chloro-5-(3-methyl-1H-indol-7-ylamino)-3H-pyrido[3,4-d]pyridazin-4-one (177 mg, 0.543 mmol) in NMP (1 ml) in a sealable glass vial, was added DIPEA (0.190 ml, 1.087 mmol) and tert-butyl(1S,2R)-2-aminocyclohexylcarbamate (233 mg, 1.087 mmol). The vial was capped to close and the reaction mixture was heated on a sandbath at 120° C. for 3 days. The resulting mixture was poured into water (20 ml), and extracted with EtOAc (20 ml). The organic phase was washed with water and brine, dried over Na2SO4, then concentrated under vacuum. The residue was triterated with DCM, then collected by filtration and dried to give a gummy solid.

1. customThe vial was capped
2. customto close
3. extractionextracted with EtOAc (20 ml)
4. washThe organic phase was washed with water and brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated under vacuum
7. filtrationcollected by filtration
8. customdried
9. customto give a gummy solid