Hydrochloric Acid → HCID 178427324, compound

HRID 629303Notes

Reaction equation

[F:1][C:2]1[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:3]=1[O:4][C:5]1[C:19]([C:20]2[C:21]3[CH:30]=[CH:29][N:28]([S:31]([C:34]4[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=4)(=[O:33])=[O:32])[C:22]=3[C:23](=[O:27])[N:24]([CH3:26])[CH:25]=2)=[CH:18][C:8]2[N:9](C3CCCCO3)[N:10]=[N:11][C:7]=2[CH:6]=1.Cl.O>CO>[F:1][C:2]1[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:3]=1[O:4][C:5]1[C:19]([C:20]2[C:21]3[CH:30]=[CH:29][N:28]([S:31]([C:34]4[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=4)(=[O:33])=[O:32])[C:22]=3[C:23](=[O:27])[N:24]([CH3:26])[CH:25]=2)=[CH:18][C:8]2[NH:9][N:10]=[N:11][C:7]=2[CH:6]=1

Participants

Conditions

Temperature: 20 °C

Procedure

A solution of 4-[5-(2,4-difluorophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,3-benzotriazol-6-yl]-6-methyl-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one (0.077 g, 0.12 mmol) in methanol (0.34 mL) was treated with 6.0 M hydrogen chloride in water (0.102 mL, 0.610 mmol) and stirred at 20° C. for 22 h. The reaction mixture was concentrated to give a crude residue that was used immediately without further purification.

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-c22f635e1dff4ee089cc4c05fa27d4f4
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315501B2

Reaction notes

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