反应详情

A solution of 3-bromo-2,4-difluoroaniline (4.16 g, 20 mmol, EP184384), n-propanesulfonyl chloride (4.6 ml, 40 mmol), pyridine (8 ml), DMAP (97 mg), and DCM (100 ml) was stirred at rt for 16 h. Aqueous sodium bicarbonate solution was added and the mixture was extracted with ethyl acetate. The organic layer was washed with aqueous sodium bicarbonate and brine. The crude product was purified by silica gel chromatography (8:1 to 3:1 hexanes/ethyl acetate eluant) to give the title compound. MS m/z 313.9 (M+1).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with aqueous sodium bicarbonate and brine
3. customThe crude product was purified by silica gel chromatography (8:1 to 3:1 hexanes/ethyl acetate eluant)