反应详情

To a solution of ethyl 4-(4-(adamantan-1-yl)phenoxy)butanoate (1.1 g, 3.50 mmol) in H2O/THF (1 mL/1.20 mL) was added lithium hydroxide monohydrate (0.14 g, 7.00 mmol), and stirred at room temperature overnight. The reaction mixture was adjusted to acidic solution with 1 N aqueous HCl and extracted with dichloromethane. The organic layer was washed with H2O and brine, and dried over anhydrous magnesium sulfate. The solvent was filtered and evaporated under reduced pressure to afford a crude solid, which was purified by silica gel column chromatography to give 4-(4-(adamantan-1-yl)phenoxy)butanoic acid as a white solid (0.98 g, 97.12% yield).

1. extractionextracted with dichloromethane
2. washThe organic layer was washed with H2O and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationThe solvent was filtered
5. customevaporated under reduced pressure
6. customto afford a crude solid, which
7. customwas purified by silica gel column chromatography