Ammonium Hydroxide → 3-Cyano-4-fluorobenzene-1-sulfonamide

HRID 629586Notes

Reaction equation

HRID 629586 reaction equation
[OH-].[NH4+:2].[C:3]([C:5]1[CH:6]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[CH:8]=[CH:9][C:10]=1[F:11])#[N:4]>Cl>[C:3]([C:5]1[CH:6]=[C:7]([S:12]([NH2:2])(=[O:14])=[O:13])[CH:8]=[CH:9][C:10]=1[F:11])#[N:4]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 27789083-Cyano-4-fluorobenzenesulfonyl chloride

Product 1

HCID 251398973-Cyano-4-fluorobenzene-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Concentrated ammonium hydroxide (28% solution in water, 3.17 mL) was cooled to 0° C. and 3-cyano-4-fluorobenzene-1-sulfonyl chloride (1.00 g) was added. The solution was mixed at 0° C. for four minutes. 4M HCl (10 mL) was added slowly and the solution was extracted with ethyl acetate. The extract was dried on brine and anhydrous sodium sulfate and the solvent removed under vacuum.

Workup

  1. additionThe solution was mixed at 0° C. for four minutes
  2. extractionthe solution was extracted with ethyl acetate
  3. dry with materialThe extract was dried on brine and anhydrous sodium sulfate
  4. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-2fbc3884d6de4b2496b49b93cc22639b
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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