反应详情

A mixture of tert-butyl piperidin-4-ylcarbamate (45 g) and dihydro-2H-pyran-4(3H)-one (24.74 g) in dichloromethane (1000 mL) was treated with sodium triacetoxyborohydride (61.9 g), stirred at room temperature for 16 hours, washed with 1M sodium hydroxide and dried with anhydrous sodium sulfate, filtered and concentrated. The concentrate was flash column chromatographed on silica gel with 10-20% methanol/dichloromethane.

1. washwashed with 1M sodium hydroxide
2. dry with materialdried with anhydrous sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customchromatographed on silica gel with 10-20% methanol/dichloromethane