Acetic Anhydride → HCID 67126416, compound

HRID 629662Notes

Reaction equation

HRID 629662 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:11][C:10]=2[N+:19]([O-:21])=[O:20])[CH2:2]1.C(N(C(C)C)C(C)C)C.[C:31](OC(=O)C)(=[O:33])[CH3:32]>ClCCl.CN(C)C=O>[C:31]([N:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:16])=[O:17])=[CH:11][C:10]=2[N+:19]([O-:21])=[O:20])[CH2:2]1)(=[O:33])[CH3:32]

Participants

6

Reactant 3

HCID 7918Acetic AnhydrideHCID 81531DiisopropylethylamineHCID 67126454HCID 67126454, compound

Product 1

HCID 67126416HCID 67126416, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 415B (145 mg) and N-ethyl-N-isopropylpropan-2-amine (120 μl) in anhydrous dichloromethane (5 mL) and N,N-dimethylformamide (2 mL) was cooled with an ice bath and acetic anhydride (56 μl) was added dropwise. The mixture was stirred at room temperature for 3 hours and concentrated to dryness. The residue was triturated with water. The resulting solid was dried under vacuum to give the title compound.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was triturated with water
  3. customThe resulting solid was dried under vacuum

Sources & evidence

ORD record
ord-74b01a5c08874139a6acd9564a8ed5a1
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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