反应详情

To a 0° C. mixture of lithium aluminum hydride (300 mg, 7.9 mmol) in anhydrous THF (10 mL) was slowly added a solution of ethyl 4-(propan-2-yl)-1,3-thiazole-5-carboxylate (1.06 g, 6.1 mmol) in anhydrous THF (10 mL). The reaction mixture was stirred at room temperature for 1.5 hours. After cooling to 0° C., water (20 mL) and EtOAc (40 mL) were added. The mixture was stirred for 30 minutes. The solid material was removed by filtration. The organic layer was recovered. The aqueous layer was extracted with EtOAc (2×20 mL). The combined organic extracts were dried over MgSO4, filtered, evaporated, and dried in vacuo, affording [4-(propan-2-yl)-1,3-thiazol-5-yl]methanol (802 mg, 96% yield). The product was used without further purification.

1. temperatureAfter cooling to 0° C.
2. stirringThe mixture was stirred for 30 minutes
3. customThe solid material was removed by filtration
4. customThe organic layer was recovered
5. extractionThe aqueous layer was extracted with EtOAc (2×20 mL)
6. dry with materialThe combined organic extracts were dried over MgSO4
7. filtrationfiltered
8. customevaporated
9. customdried in vacuo