反应详情

m-Chloroperoxybenzoic acid (77%, 2.10 g, 9.42 mmol) in dichloromethane (20 mL) was added at 0° C. to a solution of (1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino) methanone (4.8 g, 11.08 mmol) in dry dichloromethane (300 mL). The mixture was stirred at room temperature for 3 h and then poured onto saturated sodium sulfite solution. The organic layer was separated after stirring for 15 min and washed with saturated sodium hydrogen carbonate solution and brine. The organic phase was dried over sodium sulfate and concentrated and the remnant was purified by flash column chromatography [dichloromethane with 2.5% methanol]. White solid. Yield: 3.2 g

1. customThe organic layer was separated
2. stirringafter stirring for 15 min
3. washwashed with saturated sodium hydrogen carbonate solution and brine
4. dry with materialThe organic phase was dried over sodium sulfate
5. concentrationconcentrated
6. customthe remnant was purified by flash column chromatography [dichloromethane with 2.5% methanol]