反应详情

1.53 g (2.38 mmol) of the compound from example 17A was dissolved in 18 ml dimethyl formamide and 0.47 ml (4.79 mmol) DIEA was added. After one hour reaction time, the raw product was purified by preparative RP-HPLC on a C18 column with a water methanol gradient from 9/1 to 1/9. The product-containing fractions were combined and concentrated to dryness under reduced pressure. This gave 416 mg (0.97 mmol, 40% of theory) of the desired product.

1. customAfter one hour reaction time
2. customthe raw product was purified by preparative RP-HPLC on a C18 column with a water methanol gradient from 9/1 to 1/9
3. concentrationconcentrated to dryness under reduced pressure