Sodium hydride → 3-(6-(3-Chloropropoxy)-7-methoxyquinazolin-4-ylthio)aniline

HRID 631558Notes

Reaction equation

HRID 631558 reaction equation
[H-].[Na+].[NH2:3][C:4]1[CH:5]=[C:6]([SH:10])[CH:7]=[CH:8][CH:9]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:27][CH3:28])=[C:19]([O:22][CH2:23][CH2:24][CH2:25][Cl:26])[CH:20]=2)[N:15]=[CH:14][N:13]=1>C1COCC1>[Cl:26][CH2:25][CH2:24][CH2:23][O:22][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][C:18]=1[O:27][CH3:28])[N:15]=[CH:14][N:13]=[C:12]2[S:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[NH2:3]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 315773-AminothiophenolHCID 507422644-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline

Product 1

HCID 668766163-(6-(3-Chloropropoxy)-7-methoxyquinazolin-4-ylthio)aniline

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a round bottomed flask, sodium hydride (121 mg, 3.14 mmol), a 60% dispersion in mineral oil, was suspended in 20 mL of dry THF. To this suspension 3-aminothiophenol (394 mg, 3.14 mmol) was added and the reaction stirred for 30 minutes. To this solution 4-chloro-6-(3-chloropropoxy)-7-methoxyquinazoline (900 mg, 3.14 mmol) and the reaction stirred overnight. The reaction was quenched with water, concentrated, and partitioned between water and ethyl acetate. After extracting twice, the extracts were combined, dried over magnesium sulfate, filtered and concentrated to give 3-(6-(3-chloropropoxy)-7-methoxyquinazolin-4-ylthio)aniline as a yellow solid and used without further purification. 1H(DMSO-d6) 8.70 (s, 1H), 7.34 (s, 1H), 7.15 (m, 1H), 6.80 (s, 1H), 6.75 (m, 2H), 4.28 (m, 2H), 3.99 (s, 3H), 3.84 (m, 2H), 2.38 (m, 2H); LCMS (ESI) m/z 376 (M+H).

Workup

  1. customThe reaction was quenched with water
  2. concentrationconcentrated
  3. custompartitioned between water and ethyl acetate
  4. extractionAfter extracting twice
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-c262e0ab01494be0a897b3daee1576be
Source dataset
uspto-grants-2016_04
Patent number
US09320739B2

Reaction notes

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